Practical Training: Immunocytochemical Staining of Human Postmortem Tissue and Evaluation of the Staining Using the Multihead Microscope

Faculty of Psychology and Neuroscience

Practical Training: Immunocytochemical Staining of Human Postmortem Tissue and Evaluation of the Staining Using the Multihead Microscope

Full course description

An immunocytochemical procedure will be followed to label plaques (ABeta) and the staining will be evaluated afterwards using the multihead microscope.

The final assessment for this course is pass or fail - and not a numerical grade between 0,0 and 10,0.

Course objectives

Students will be able to understand:

  • collecting Postmortem tissue, fixation, paraffin, immunocytochemical staining, recognition of neuropathological hallmarks in Tauopathies: Alzheimer’s disease (AD);
  • plaques, tangles;
  • early and late onset AD, Amyloid beta cascade hypothesis, amyloid precursor protein, Tau, ubiquitin, GFAP, gliosis, cytoarchitecture of hippocampus and neocortex.
PSY4351
Period 2
28 Oct 2024
20 Dec 2024
Print course description
ECTS credits: 
0.0
Instruction language: 
English
Coordinator:
Teaching methods: 
Lecture(s), Skills
Assessment methods: 
Attendance, Observation, Assignment
Keywords: 
Tauopathies (e.g. Alzheimer’s), neurodegenerative mechanisms