Molecular Biology
Full course description
The general aim of this course is to obtain detailed knowledge about the molecular processes in cell signaling and control of gene expression. Topics include intracellular signaling pathways; chromatin structure and remodeling; recruitment and assembly of transcription factors; eukaryote mRNA synthesis, processing, modification, stability and translation; stem cells and reprogramming; and the culmination of the above factors that drive common complex human disease. The tutorials will be partially in Problem Based Learning (PBL) and multiple-choice format, with exercises designed to provide a perspective of how cutting edge molecular biological techniques are applied to tackle major research questions in modern biomedical research.
Course objectives
- To get acquainted with the best-characterized cell signaling mechanisms in eukaryotic cells;
- To understand gene structure/function and different gene regulatory mechanisms (chromatin remodeling and (post)transcriptional regulation) in prokaryotes and eukaryotes;
- To understand how molecular biology, when used in combination with other biological disciplines (e.g. biochemistry, genetics, imaging), can provide tools to understand (diagnostics) and intervene (therapy) in the cellular complexity of human disease.
Prerequisites
- BIO2001
- BIO2007
Co-requisites
- PRA3003
Recommended reading
Recommended literature source are:
- “Molecular Cell Biology” by Lodish, Berk, Kaiser (W.H. Freeman,8thedition, 2016);
- “Introduction to Genetic Analysis” by Griffiths, Wessler, Carrol, Doebley (W.H. Freeman,10thedition, International Edition, 2012);
- “Molecular biology of the Cell” by Alberts et al. Additional literature will be provided as a reader.