Molecular Biology
Volledige vakbeschrijving
The general aim of this course is to obtain detailed knowledge about the molecular processes in cell signalling and control of gene expression. Topics include intracellular signalling pathways; chromatin structure and remodelling; recruitment and assembly of transcription factors; eukaryote mRNA synthesis, processing, modification, stability and translation; stem cells and reprogramming; and the culmination of the above factors that drive common complex human disease. The tutorials will be partially in Problem Based Learning (PBL) and multiple-choice format, with exercises designed to provide a perspective of how cutting edge molecular biological techniques are applied to tackle major research questions in modern biomedical research.Doelstellingen van dit vak
• To get acquainted with the best-characterized cell signaling mechanisms in eukaryotic cells. • To understand gene structure/function and different gene regulatory mechanisms (chromatin remodeling and (post)transcriptional regulation) in prokaryotes and eukaryotes. • To understand how molecular biology, when used in combination with other biological disciplines (e.g. biochemistry, genetics, imaging), can provide tools to understand (diagnostics) and intervene (therapy) in the cellular complexity of human disease.Voorwaarden
Pre-requisites BIO2001 Cell Biology BIO2007 Genetics Co-requisites PRA3003 Molecular BiologyAanbevolen literatuur
A reader is provided at the start of the course. Other recommended literature source: "Molecular Cell Biology" by Lodish, Berk, Kaiser (W.H. Freeman, 7thedition, 2012. bol.com price €145, international Edition available at amazon.com for a lower price), "Introduction to Genetic Analysis" by Griffiths, Wessler, Carrol, Doebley (W.H. Freeman, 10thedition, International Edition, 2012. bol.com price €64,99), "Molecular biology of the Cell" by Alberts et al.BIO3001
Periode 2
28 okt 2024
20 dec 2024
Periode 5
7 apr 2025
6 jun 2025
Studiepunten:
5.0Taal van de opleiding:
EngelsCoordinators:
Onderwijsmethode:
Lecture(s), PBLEvaluatiemethoden:
Attendance, Participation, Written exam