Immune Responses in Health and Disease
Full course description
The immune system is a remarkable natural system that is proving to be of great inspiration to scientists, medical staff and students. It is ubiquitous in present life. This course provides a detailed study of the functioning of the immune system. Students acquire insights into the molecular and cellular interactions and functioning of the immune system in normal conditions. Topics include the development of immune cells, humoral and cell-mediated immunity, and tolerance. During the past decades, evidence has mounted that many (chronic) diseases are characterized by an imbalance of the immune system. Moreover, we are challenged by complex situations where it is demonstrated that the immune system plays a crucial role. Therefore, the role of the immune system in a variety of diseases and complex situations (e.g. cancer, autoimmunity, neurodegenerative diseases, microbial defense, transplantation and vaccination) will be studied in an integrated way during the project week and integration assignment.
This course provides a detailed study of the function of the immune system and previous/basic knowledge of the immune system is assumed/recommended for this course.
Course objectives
ILO3014.1 Explain the structure and function of lymphoid organs and the development of leucocytes:
- Describe and draw lymphoid organs and relate the structure of lymphoid organs to their function.
- Explain the development of innate immune cells.
- Explain the development and maturation of adaptive immune cells.
- Explain the migration pathways of leucocytes in the body (during homeostasis and disease/infection).
ILO3014.2 Analyze the activation and downregulation of innate and adaptive immune responses:
- Compare the innate and the adaptive immune system during sterile and non-sterile inflammation.
- Explain the genetic base and diversity of MHC molecules and their role in disease.
- Examine the immune regulation mechanisms of the immune system.
ILO 3014.3 Explain the roles of immune cells in the innate and adaptive immune systems in health:
- Explain in time (4D), order, and function
- Gender diversity and aging
- Influence of nutrition/environment
ILO 3014.4 Understand and present the immune processes underlying immune relatedpathophysiology:
- Hypersensitivity (incl allergy and autoimmunity)
- Immunodeficiency
- Cancer
ILO 3014.5 Understand and present strategies to modulate immune responses to improve human health:
- Design a plan to translate an invention from research to clinical application.
ILO 3014.6 Explain techniques commonly used to investigate the phenotype and functionof cells in immune responses:
- Students know the basic principles and applications of serological and cellular immune tests and can correctly analyze and interpret the results.
- Students understand the selection and application of practical immunological approaches to conduct an investigation.