Analytical Science and Technology

Full course description

Next to the MSP courses on spectroscopy (CHE 2004) and mass spectrometry (INT2010, PRA 2020), the emphasis of this course will be on the technologies in analytical sciences and in the context of human biology, pharmaceutical research, bio- and polymer chemistry and chemical engineering. It will touch upon the basic physical chemical properties of molecules and the assessment of molecular structures. It forms a solid basis for chemists and biologists using analytical methodologies in their day-to-day research. Besides sample pre-treatment, molecular structure assessment, advanced separation technologies, the course focuses on the hyphenation of the analytical technologies (LC-MS/MS) and their application in chemical and biological sciences. Typical topics in the course are based on the quantification and molecular structure assessment of e.g. bio- and synthetic polymers. In the end the students should be able to design an analytical methodology.

Course objectives

To gain an understanding of analytical sciences & technologies, molecular structures, their chemical & biological properties the importance for the design of analytical methodologies;
Create a fundamental understanding in “sampling and sample pre-treatment” in the analysis of a variety of molecules like, hormones, lipids, proteins and synthetic polymers;
Insight into fundamental mechanisms of separation technologies (chromatography & electrophoresis), and correlate the chemical properties of molecules to the “mode of action” in, e.g., gas- super critical and liquid chromatography;
To obtain a fundamental understanding of the basics and application of various spectroscopic technologies, like UV/VIS, IR/Raman, MS and NMR for the assessment of molecular structures;
To become familiar with molecular structure assessment of chemicals, metabolites, bio- and synthetic polymers using hyphenated technologies, e.g. LC-MS/MS, LC- flow-NMR;
Obtain insight into different applications of analytical methodologies and acquire sufficient background for more advanced courses in chemical synthesis, polymer-, bio-chemistry and life;
To gain insight in “Process Analytical Technologies” applied by in-, at and on-line detection technologies. Application of technologies in (micro) flow- reactors.

Prerequisites

CHE2004

Co-requisites

None

Analytical Science and Technology