Process Analytical Technologies
Full course description
In nearly all manufacturing processes the safety and quality (control) assessment of the intermediate and end products is of crucial economic or even safety importance. Hence, where before the nineties of the last century the quality of all product was verified at the end of the production lane, nowadays continuous quality control in the entire production process is common practice. This approach has led to considerable time saving, and above all substantial reduction of so-called “out-of-specification” products.
Process analytical technologies (PAT) and their application are referred to as all technologies and approaches in the continuously monitoring of such production process. In particular, in chemical industry temperature of pressure sensors are used for the control of the processes. Likewise, in the most cell-based production processes of biopharmaceuticals the quality of the medium requires continuous monitoring. The continuous following on exothermic chemical reactions is crucial to prevent “run-away-reactions” being a pivotal safety assurance. PAT sciences encompass traditionally many miniaturized spectroscopic technologies, relying on fast readout of in many cases digital data, and a fundamental understanding of the production process in itself.
The main objective of this course is to deepen the knowledge on the basics of process technologies, its fundamentals, the essential technologies and their impact in process control and quality.
Course objectives
After completing this course, you are able to:
- Understand the basic concept of processing in (industrial) chemistry and biotechnology – the role of Process Analytical Technologies.
- Design sampling strategies and calibration approaches and discuss the control of out-of-equilibrium processes and control of processes.
- Utilize basic chemometric tools combined with novel artificial technology techniques for effective data handling and process understanding.
- Evaluate different quality and safety by design concepts.
- Design and utilization of monitoring and detection strategies utilizing a combination of (miniaturized) sensor technologies in e.g. flow chemistry.
Recommended reading
- Bakeev, K.A. (Ed.). (2010). Process Analytical technology: Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries (2nd ed.). Wiley.
- Skoog, D.A., West, D.M., Holler, F.J., & Crouch, S.R. (2014). Fundamentals of Analytical Chemistry (9th ed.). Cengage learning.
- Miller, J.N., Miller, J.C., & Miller, R.D. (2018). Statistics and Chemometrics for Analytical Chemistry (7th ed.). Pearson.