Biochemistry
Volledige vakbeschrijving
This course is a review of the molecular components of cells: structure and chemistry of biomolecules: amino acids, proteins, carbohydrates, nucleotides and nucleic acids, lipids and membranes. The course also discusses the mechanisms by which enzyme activity is regulated and can be manipulated. Next the course goes deeper into the biochemistry of synthesis and degradation of the above mentioned biomolecules that are the essential building blocks of cells. The theory studied in this course is also explained giving some examples of the application of biochemistry in every day life, for instance how DNA profiling works or how the structure of proteins influences their function and how this structure-function relation is important for homeostasis and disease.
Doelstellingen van dit vak
•To communicate fundamental principles governing structure, function and interactions of biological molecules to students encountering biochemistry for the first time; •To increase appreciation of the science of biochemistry; •To study the synthesis and degradation of large biomacromolecules like proteins, lipids, polysaccharides and nucleotides; •To create deeper understand of the basic principles of enzyme catalysis and inhibition; •To prepare students to enter more detailed courses on biochemistry and molecular biology to finally allow entrance to various Master programs in the life sciences.
Voorwaarden
SCI1009 Introduction to Biology or SCI 1004 Introduction to Chemistry. Students with substantial high school experience in Biology or Chemistry (For an indication of the relevant topics, see SCI-B and SCI-C, p. vi-viii) can contact the coordinator to request a waiver.
Aanbevolen literatuur
• Garrett and Grisham. Biochemistry. (4th ed.). Thomson Brooks/Cole. ISBN10 0495114642 ISBN13 9780495114642.
Instructional format
Lectures and tutorial groups. The course is subdivided into subjects, and for each subject lectures will be given on the basis of observed deficiencies.
Examination
A written final examination (open questions), an essay on a topic prepared from a list provided in the block book and peer review reports on essays written in this course.
This course is a prerequisite for the following course(s):
•SCI3004 Biochemistry II •SCI3005 Metabolism, Nutrition and Exercise •SCI3033 Physical Chemistr