The Basic Principles of Pharmacology

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The module offers the following practical trainings:

Training 1: Clinical study: drug-nutrient interaction (paracetamol study)
This training is a small clinical study into the effect of nutrients on the pharmacokinetics of a drug (paracetamol). The students analyse the samples they collected and processed themselves by means of HPLC analysis. They shall evaluate the data (on individual and group level) and write a report about this which is to hand in electronically. At the end of the module, the results of the study will be discussed during an interactive session.

Training 2: Genetic toxicity, polymorphism CYP P450
In this training students determine genetic differences between people with respect to drug-metabolising liver enzymes.

Training 3: Pharmacokinetics
During this lab training the interrelation of pharmacokinetic key parameters such as volume of distribution, dose, and clearance are practically appraised.

Computer training 1: Pharmacodynamics
This computer simulation elucidates basic principles of drug-receptor interactions and clarifies terms like (partial) agonists, antagonists, affinity (KD), EC50 (pD2) and intrinsic activity (alpha)

Computer training 2: Pharmacokinetics
A computer simulation that illustrates plasma concentration curves upon different modes of administration and allows assessing and modulating all relevant pharmacokinetic parameters in a one-compartment model.