Genomics and Proteomics

Genomics and Proteomics

Volledige vakbeschrijving

The introduction of genomics applications has added an extra dimension to the understanding of the molecular nature of life. Prerequisites were the unraveling of the genome of humans and other organisms, and the development of high-throughput methods for the simultaneous analysis of the expression levels of as much as possible genes. This course will give students insight in the analytical principles behind omics- technologies such as array-based analysis, in the information that can or cannot be obtained by the different ‘omics’-approaches, and in the novel developments of omics-applications such as miRNA arrays, analysis of the epigenome, and next generation sequencing. Specific themes of the course are trancriptomics, proteomics, metabolomics with special attention for the surplus value of combining of data from various omics- approaches as the best way to understand life. Special areas of attention are Nutrigenomics and Toxicogenomics.

Doelstellingen van dit vak

• To understand how genomics applications are used to unravel the biology of life. • To understand the basic principles of omics-techniques. • To gain insight in the advantages and limitations of genomics-based experiments. • To appreciate the surplus value of combining data from different omics-applications as a systems approach. • To provide the basis for gaining insight in bioinformatics and computational genomics.

Aanbevolen literatuur

• Drake et al. Challenges to developing proteomic-based breast cancer diagnostics. OMICS 2011. • Sweeney et al. The human gut microbiome: a review of the effect of obesity and surgically induced weight loss. JAMA Surgery, 2013 • Metzker ML. Sequencing technologies - the next generation. Nat Rev Genet. 2010 11:31-46. • Malone et al. Microarrays, deep sequencing and the true measure of the transcriptome. BMC Biology 2011. • Trifonova et al. Postgenomics diagnostics: metabolomics approaches to human blood profiling. OMICS 2013. • Mounayar et al. Nutri-metabolomics applied to taste perception phenotype. OMICS 2014.
BIO3010
Periode 4
3 feb 2025
4 apr 2025
Vakbeschrijving afdrukken
Studiepunten: 
5.0
Taal van de opleiding: 
Engels
Coördinator:
Onderwijsmethode: 
Lecture(s), PBL, Paper(s), Assignment(s)
Evaluatiemethoden: 
Attendance, Participation, Final paper, Written exam