Pathophysiology of Disease
Volledige vakbeschrijving
During the course, an introduction to normal immune system physiology will be given in the form of overview lectures to ensure the same (bachelor) level of knowledge. In addition, during weeks 2 to 7, the focus will be on understanding inflammation during pathophysiology of disease. Every week has a different theme and the students will be challenged with different diseases where immune system dysregulation plays a role. Students will be given their weekly assignments at the beginning of each week, with a prediscussion session where the expected learning goals of the week will be outlined. Thereafter, they will start pre-discussing a case in smaller groups. During the week, they will have expert lectures, e.g. workshops, technical and practical/training skills and journal club discussions. Time will be given for self-study during the week, for both team and individual work. At the end of the week the students will discuss the case they have been working on and the practical/training skill assignment. Theme week 1: Introduction to the immune system: normal physiology. Theme week 2: Innate immunity to bacteria and fungi. Theme week 3: Immunity to viruses. Theme week 4: Sterile inflammation and other pathological threats. Theme week 5: Immunity to tumors. Theme week 6: Hypersensitivity disorders and autoimmunity. Theme week 7: Microbe-host interactions in (immune) homeostasis. Week 8 consists of reflection, poster presentation and exam.
Doelstellingen van dit vak
B-ILO1202.1 Explain immunity to microbes and viruses
Recognize and compare innate and adaptive immunity to infections
Explain immune evasion by pathogens.
Discuss injurious effects of immune responses: chronic inflammation, septic shock.
B-ILO1202.2 Explain sterile inflammation and other pathological threats
Analyze the role of sterile inflammation
Discuss pathological threats such as neurodegeneration, atherosclerosis, ischemia-reperfusion, and cardiometabolic inflammation.
B-ILO1202.3 Explain immunity to tumors
Differentiate tumor immunity, tumor antigens and immune response to tumors.
Explain evasion of the immune response by tumors.
Effects of the tumor microenvironment.
The role of the immune system in promoting tumor growth/tumor progression.
B-ILO1202.4 Explain hypersensitivity disorders and autoimmunity
Recognize diseases caused by hypersensitivity disorders.
Discuss immunological diseases, their pathogenesis and current therapy.
Explain IgE and mast cell-dependent reactions and allergic reactions.
B-ILO1202.5 Explain microbe-host interactions in (immune) homeostasis
Discuss interplay between microbial colonization and the development of the immune system/induction of tolerance
Recognize the induction of (innate) immune responses by microbes at mucosal interfaces
Know how microbiota regulates metabolic and immune homeostasis
Recognize microbial dysbiosis and its role in immune-mediated disease predisposition