Medical Microbiology

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The ultimate goal of this course is to introduce the students to the field of biomaterials science. Biomaterials are (mostly synthetic) materials that are intended to improve treatment humans or animals. There are different classes of biomaterials, among which are synthetic and biobased (green) polymers, ceramics, fibers, etc. The exact structure and physico-chemical characteristics of these biomaterials will be explained. For instance, the exact composition, elasticity, biodegradation, chemical reactivity, stability, surface chemistry and topology are important parameters. The techniques that are used to evaluate the physical, chemical and biological characteristics of biomaterials are, consequently, an important subject in this course. Biomaterials are used in contact with tissues, the skin, or body-fluids and have to possess a number of special characteristics to be applicable. The response that is provoked from the contacting tissue is critically important. Therefore, the exact interaction between tissue and cells with the different biomaterials has to be studied. The concepts of biocompatibility, biosafety, toxicity, blood- and cyto- compatibility will be introduced and explained in this course. Detailed information on the methods that are used to determine the biological response of a biomaterial will be provided. In the practical part of the course the students will be introduced to basic techniques involved in the characterization of biomaterials and determination of biocompatibility.